![]() Thus, host immunome and diseasome should be precisely regulated by gene networks to maintain balance between immune response and pathogen colonization. Fungal invasion is orchestrated by set of genes that exhibit induction and/or repression during infection dictating host’s ability to mitigate and pathogen to propagate in plant-microbe interactions 2. Plant innate immunity can be activated by microbe, chitin or pathogen-associated molecular patterns (M/C/PAMPs) in accurate manner and determined by transcription factors and extensive transcriptional reprogramming. Although sequence of recognition, signal transduction and response is common theme but selection in plant is unique to type of pathogen attack contributing to disease or resistance 1. It is a monolayer paradigm in which mounting resistance in host is counter-balanced by deregulated pathogen virulence. Several of these stresses are united by the fact that at least part of their detrimental effect on plant performance is caused by the deregulation of the immune status. Counter action strategies are pre-requisite for assault and defense against virulence factors of pathogen and innate immune system of plants. Plants frequently encounters to wide range of patho-stresses that modulate growth and development thereby affecting the overall productivity. Our regularized network with robust statistical assessment captured known and unexpected gene interaction, candidate novel regulators as future biomarkers and first time showed system-wide quantitative architecture corresponding to genotypic characteristics in wilt landscape. Furthermore, we identified core 76 disease/immunity related genes through subcellular analysis. These subnetworks likely represent key components that coordinate various biological processes favouring defence or disease. Functional enrichment revealed immunome containing three subnetworks involving CTI, PTI and ETI and wilt diseasome encompassing four subnetworks highlighting pathogen perception, penetration, colonization and disease establishment. Global network analysis identified five major hubs with 389 co-regulated genes. Integrative gene-regulatory network elucidated tangible insight into interaction coordinators leading to pathway determination governing distinct (disease or immune) phenotypes. Here, we temporally profiled two contrasting chickpea genotypes in disease and immune state to better understand gene expression switches in host specific resistance. Vascular wilt caused by root pathogen Fusarium species is complex and governed by host specific resistance in crop plants, including chickpea. Gene network organizing principles leading to quantitative differences in resistant and susceptible host during host specific resistance are poorly understood. Host specific resistance and non-host resistance are two plant immune responses to counter pathogen invasion.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |